Chrome needs an extension, 'Meta4 ClickOnce', to be able to use the Sapphire Configurator.
Click the first link
Click Add to Chrome in the top right of the pop up.
A popup will appear. Click 'Add extension'.
A program will download in the bottom left corner of the Chrome Window.
Another popup will confirm the extension was installed correctly
To confirm the extension is there, there is an icon to the right of the address bar.